Secondary Prevention of Cervical Cancer

Class II – Findings Suggesting a Limited Protective Value

Class II-p

Squamous epithelial cells with milder nuclear changes than in CIN 1, also with koilocytotic cytoplasm or parakeratosis.

Example of class II-p:

Eosinophilic and basophilic squamous epithelial cells with an increased nuclear-cytoplasmic ratio in a 34-year-old patient. Cytology at 6 months’ follow-up was normal.

Class II-g

Cervical glandular cells with anomalies that go beyond the spectrum of reactive changes.

Example of class II-g:

Basophilic glandular epithelial cells of the endocervix with an increased nuclear-cytoplasmic ratio in a 31-year-old patient.

Class II-e

Endometrial cells in women > age 40 in the second half of their menstrual cycle.

Example of class II-e:

Syncytium of eosinophilic glandular epithelial cells of the endometrium with an increased nuclear-cytoplasmic ratio in a 48-year-old patient, 3 weeks after her last menstrual period. Office hysteroscopy showed a normal appearing uterine cavity with normal mucosa. Endometrial biopsy confirmed normal endometrium.